Mayo Clinic, Jacksonville, FL.
To impact human health research.
My research interests are currently focused on Alzheimer's disease and other neurodegenerative diseases, like ALS and FTD. I also research the effects of genome structure on physical attributes (phenotypes), generally, using Computation Biology and Bioinformatics. My research ranges from algorithms to understand the underlying biology, to large-scale disease studies. Computational biology and Bioinformatics are an important part in all of this.
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's disease) is a fatal neurodegenerative disease that often strikes relatively suddenly between 45 and 55. Symptoms include progressive muscle weakness in the extremities and/or muscles required for swallowing or breathing. Longevity can range from six months to five years. It is also genetically linked to Frontotemporal Dementia (FTD). My approaches involve long-read and single-cell sequencing.
Alzheimer's disease requires little introduction. It is a leading cause of death in the elderly, and is well known for its symptoms involving memory loss. This disease is painful for everyone involved, including loved ones. I am also applying long-read and single-cell sequencing in this disease.
I'm fascinated with genomics, generally.
First or corresponding-author Publications
Funding (PI or Co-PI)