Mark T. W. Ebbert, Assistant Professor
Neuroscience Department
Mayo Clinic, Jacksonville, FL.

Current Research


To impact human health research.


My research interests are currently focused on Alzheimer's disease and other neurodegenerative diseases, like ALS and FTD. I also research the effects of genome structure on physical attributes (phenotypes), generally, using Computation Biology and Bioinformatics. My research ranges from algorithms to understand the underlying biology, to large-scale disease studies. Computational biology and Bioinformatics are an important part in all of this.

Current Projects

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Amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's disease) is a fatal neurodegenerative disease that often strikes relatively suddenly between 45 and 55. Symptoms include progressive muscle weakness in the extremities and/or muscles required for swallowing or breathing. Longevity can range from six months to five years. It is also genetically linked to Frontotemporal Dementia (FTD). My approaches involve long-read and single-cell sequencing.

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Alzheimer's disease

Alzheimer's disease requires little introduction. It is a leading cause of death in the elderly, and is well known for its symptoms involving memory loss. This disease is painful for everyone involved, including loved ones. I am also applying long-read and single-cell sequencing in this disease.

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I'm fascinated with genomics, generally.



Total Publications


First or corresponding-author Publications


Book Chapter


Funding (PI or Co-PI)

Key Publications

Explore key publications I have contributed to by category
Dark and Camouflaged genes — Genome Biology
Long-read sequencing in C9orf72 — Molecular Neurodegeneration
Poly(GR) mouse model — Nature Medicine
Methylation in ALS — Acta Neuropathologica
Variant Tool Chest — BMC Bioinformatics
Genetic Interactions in Alzheimer's disease — Biological Psychiatry
Tumor Grafts from Women Reflect Tumor Pathology and Outcome — Nature Medicine
Epistasis in Alzheimer's disease — Alzheimer's and Dementia
Tracking HIV Infection Through Viral Sequence — J. Clin. Virology
PCR Duplicate Removal Unnecessary — BMC Bioinformatics
An Algorithm to Characterize Systematic Error to Present Personalized Clinical Test Scores — J. Clin. Biinformatics
Review: Bridging the Gap Between Statistical and Biological Epistasis
Review: Genetic Discoveries in AD Using CSF Amyloid and Tau
Review: Genetics of Alzheimer's disease
TREM2 R47H in the Cache County Study
PAM50 Breast Cancer Subtyping
Feel free to get in touch, or take a look at my current Curriculum Vitae.